Dr. Rodrigo Herrera Molina

El Dr. Herrera recibió su grado de Bioquímico de la Universidad Chile en el año 2004. En el año 2010 recibió su grado de Doctor en Ciencias Biomédicas de la misma casa de estudios.

Líneas de Investigación


    1. García F, Lobos P, Ponce A, et al. Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation. Mar Drugs. 2020;18(6):E335. Published 2020 Jun 26. doi:10.3390/md18060335
    2. Luarte A, Henzi R, Fernández A, et al. Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity. Cells. 2020;9(4):930. Published 2020 Apr 10. doi:10.3390/cells9040930
    3. Ilic K, Auer B, Mlinac-Jerkovic K, Herrera-Molina R. Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?. Front Cell Dev Biol. 2019;7:27. Published 2019 Mar 7. doi:10.3389/fcell.2019.00027
    4. Bruna B, Lobos P, Herrera-Molina R, Hidalgo C, Paula-Lima A, Adasme T. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K. Biochem Biophys Res Commun. 2018;505(1):201-207. doi:10.1016/j.bbrc.2018.09.080
    5. Lang D, Schott BH, van Ham M, et al. Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition. J Neuroinflammation. 2018;15(1):216. Published 2018 Aug 1. doi:10.1186/s12974-018-1242-1
    6. Lagos-Cabré R, Brenet M, Díaz J, et al. Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration. Int J Mol Sci. 2018;19(8):2179. Published 2018 Jul 26. doi:10.3390/ijms19082179
    7. Lagos-Cabré R, Alvarez A, Kong M, et al. αVβ3 Integrin regulates astrocyte reactivity. J Neuroinflammation. 2017;14(1):194. Published 2017 Sep 29. doi:10.1186/s12974-017-0968-5
    8. Korthals M, Langnaese K, Smalla KH, et al. A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation. Sci Rep. 2017;7(1):8358. Published 2017 Aug 21. doi:10.1038/s41598-017-08519-4
    9. Herrera-Molina R, Mlinac-Jerkovic K, Ilic K, et al. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration. Sci Rep. 2017;7(1):7273. Published 2017 Aug 4. doi:10.1038/s41598-017-07839-9
    10. Maldonado H, Calderon C, Burgos-Bravo F, et al. Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochim Biophys Acta Mol Cell Res. 2017;1864(2):243-254. doi:10.1016/j.bbamcr.2016.11.006
    11. Bhattacharya S, Herrera-Molina R, Sabanov V, et al. Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation. Biol Psychiatry. 2017;81(2):124-135. doi:10.1016/j.biopsych.2016.03.2107
    12. Beesley PW, Herrera-Molina R, Smalla KH, Seidenbecher C. The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. J Neurochem. 2014;131(3):268-283. doi:10.1111/jnc.12816
    13. Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, et al. Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. J Biol Chem. 2014;289(13):8973-8988. doi:10.1074/jbc.M113.514992
    14. Sandoval M, Luarte A, Herrera-Molina R, et al. The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment. Brain Res. 2013;1520:1-14. doi:10.1016/j.brainres.2013.04.049
    15. Kong M, Muñoz N, Valdivia A, et al. Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta. 2013;1833(6):1409-1420. doi:10.1016/j.bbamcr.2013.02.013
    16. Herrera-Molina R, Valdivia A, Kong M, et al. Thy-1-interacting molecules and cellular signaling in cis and trans. Int Rev Cell Mol Biol. 2013;305:163-216. doi:10.1016/B978-0-12-407695-2.00004-4
    17. Herrera-Molina R, Flores B, Orellana JA, von Bernhardi R. Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: a role for STAT1 and MAPK pathways. J Neurochem. 2012;123(1):113-123. doi:10.1111/j.1471-4159.2012.07887.x
    18. Sarto-Jackson I, Milenkovic I, Smalla KH, et al. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. J Biol Chem. 2012;287(17):14201-14214. doi:10.1074/jbc.M111.293175
    19. Herrera-Molina R, Frischknecht R, Maldonado H, et al. Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1. PLoS One. 2012;7(3):e34295. doi:10.1371/journal.pone.0034295
    20. Henríquez M, Herrera-Molina R, Valdivia A, et al. ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation. J Cell Sci. 2011;124(Pt 9):1581-1588. doi:10.1242/jcs.073171
    21. Henríquez M, Herrera-Molina R, Valdivia A, et al. ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation. J Cell Sci. 2011;124(Pt 9):1581-1588. doi:10.1242/jcs.073171
    22. Avalos AM, Valdivia AD, Muñoz N, et al. Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. J Cell Sci. 2009;122(Pt 19):3462-3471. doi:10.1242/jcs.034827
    23. Uribe-San Martín R, Herrera-Molina R, Olavarría L, Ramírez G, von Bernhardi R. Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta. Neuroscience. 2009;158(4):1338-1347. doi:10.1016/j.neuroscience.2008.11.002
    24. Hermosilla T, Muñoz D, Herrera-Molina R, et al. Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication. Biochim Biophys Acta. 2008;1783(6):1111-1120. doi:10.1016/j.bbamcr.2008.01.034
    25. Saud K, Herrera-Molina R, Von Bernhardi R. Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotox Res. 2005;8(3-4):277-287. doi:10.1007/BF03033981
    26. Herrera-Molina R, von Bernhardi R. Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture. Neurobiol Dis. 2005;19(1-2):229-236. doi:10.1016/j.nbd.2005.01.003
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